Coronavirus disease 2019 in pregnancy.

OBJECTIVES: This study aimed to compare clinical courses and outcomes between pregnant and reproductive-aged non-pregnant women with COVID-19, and to assess the vertical transmission potential of COVID-19 in pregnancy. METHODS: Medical records of pregnant and reproductive-aged non-pregnant women hospitalized with COVID-19 from January 15 to March 15, 2020 were retrospectively reviewed. The severity of disease, virus clearance time, and length of hospital stay were measured as the primary objective, while the vertical transmission potential of COVID-19 was also assessed. RESULTS: Eighty-two patients (28 pregnant women, 54 reproductive-aged non-pregnant women) with laboratory-confirmed COVID-19 were enrolled in this study. Univariate regression indicated no association between pregnancy and severity of disease (OR 0.73, 95% CI 0.08-5.15; p=0.76), virus clearance time (HR 1.16, 95% CI 0.65-2.01; p=0.62), and length of hospital stay (HR 1.10, 95% CI 0.66-1.84; p=0.71). Of the pregnant women, 22 delivered 23 live births, either by cesarean section (17, 60.7%) or vaginal delivery (5, 17.9%), and no neonate was infected with SARS-CoV-2. CONCLUSIONS: Pregnant women have comparable clinical courses and outcomes with reproductive-aged non-pregnant women when infected with SARS-CoV-2. No evidence supported vertical transmission of COVID-19 in the late stage of pregnancy, including vaginal delivery.

Clinical observation of different treatment strategies in pregnant women with COVID-19: a retrospective study (preprint)

Objective: this study aimed to clarify the clinical characteristics, obstetrical and fetal outcomes of patients with Corona Virus Disease 2019 (COVID-19) in different stage during pregnancy.Methods: 13 pregnant women with COVID-19 were admitted to Wuhan central hospital and Renmin hospital of Wuhan university between Jan 20 and march 20, 2020, including four patients in first and second trimester demanding for pregnancy termination, seven in first and second trimester and two in third trimester keeping pregnancy. The two groups’ clinical characteristics, treatment and maternal and fetal outcomes were observed and analyzed.Results: Most common clinical manifestation were fever and cough. Among the patients keeping pregnancy, one had a spontaneous miscarriage and fetal malformation was found in another one. Two patients who had a vaginal delivery presented good maternal and neonatal outcomes. All patients showed a good recovery. Conclusion: SARS-COV-2 infection could cause spontaneous miscarriage and fetal malformation in early pregnancy.